ABSTRACT
Objective:To evaluate the effect of Qianyang Huoxue Ointment in the adjuvant treatment of patients with hypertension and blood-stasis yang hyperactivity.Methods:According to random number table method, 60 patients with hypertension of blood-stasis yang hyperactivity in The First Affiliated Hospital of University of Science and Technology of China were divided into two groups between January 2020 and June 2021, 30 in each group. The control group was given routine anti-hypertension therapy, while observation group was treated with Qianyang Huoxue Ointment on basis of control group. All patients were continuously treated for 28 d. Before and after treatment, TCM symptoms were scored. 24h ambulatory blood pressure were recorded. The blood pressure was measured before treatment and at 7, 14 and 28 d after treatment. Adverse events during treatment were recorded. Clinical efficacy and efficacy on TCM syndromes were evaluated.Results:The differences in total clinical response rate between observation group and control group were statistically significant [93.3% (28/30) vs. 70.0% (21/30), χ 2=5.46, P=0.020], and differences in total response rate of efficacy on TCM syndromes between observation group and control group were statistically significant [90.0% (27/30) vs. 66.7% (20/30), χ2=4.81, P=0.028]. After treatment, scores of TCM syndromes (dizziness, headache, burning sensation, insomnia, tinnitus, forgetfulness, soreness and weakness of waist and knees) and total score in observation group were significantly lower than those in the control group ( t=5.77, 7.02, 6.97, 6.31, 6.23, 7.49, 9.60, 8.16, P<0.01). At 7, 14 and 28 d after treatment, levels of systolic blood pressure and diastolic blood pressure in observation group were significantly lower than those in the control group ( F=99.18, 49.32, P<0.001). At 24 hour after treatment, levels of systolic blood pressure [(143.91±5.04)mmHg vs. (149.18±4.93)mmHg, t=4.09] and diastolic blood pressure [(92.35±2.98)mmHg vs. (95.66±2.97)mmHg, t=4.31] in observation group were significantly lower than those in the control group ( P<0.01). There were no significant adverse events between both groups. Conclusion:The application of Qianyang Huoxue Ointment on basis of routine western medicine can improve clinical symptoms, control blood pressure level and improve clinical efficacy in the patients with hypertension of blood-stasis yang hyperactivity.